کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9194518 | 1580502 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of pixantrone on immune-cell function in the course of acute rat experimental allergic encephalomyelitis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Pixantrone is an immunesuppressor similar to mitoxantrone but with lower cardiotoxicity. We evaluated the effect of pixantrone on B cells and lymphomononuclear cells in the course of acute EAE. Pixantrone reduced the number of B cells and suppressed myelin basic protein (MBP) specific IgG production. In vitro, pixantrone induced apoptosis of rat B lymphocytes in a way similar to mitoxantrone. In addition, pixantrone inhibited antigen specific and mitogen induced lymphomononuclear cell proliferation, as well as IFN-γ production, during EAE. These findings suggest a similar mechanism of action for pixantrone and mitoxantrone on the effector function of lymphomonocyte B and T cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 168, Issues 1â2, November 2005, Pages 111-117
Journal: Journal of Neuroimmunology - Volume 168, Issues 1â2, November 2005, Pages 111-117
نویسندگان
Benedetta Mazzanti, Tiziana Biagioli, Alessandra Aldinucci, Guido Cavaletti, Ennio Cavalletti, Norberto Oggioni, Maura Frigo, Stefania Rota, Elena Tagliabue, Clara Ballerini, Luca Massacesi, Paolo Riccio, Francesco Lolli,