کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9194541 | 1580509 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interleukin-1β potentiates neuronal injury in a variety of injury models involving energy deprivation
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Interleukin-1β potentiates neuronal injury in a variety of injury models involving energy deprivation Interleukin-1β potentiates neuronal injury in a variety of injury models involving energy deprivation](/preview/png/9194541.png)
چکیده انگلیسی
The purpose of this study was to develop a suitable in vitro model system to study the biochemical pathway(s) by which interleukin-1β (IL-1β) contributes to the pathogenesis of cerebral ischemia. Thus, the effect of IL-1β on a number of injury paradigms associated with energy deprivation was investigated using murine mixed cortical cell cultures. While IL-1β by itself was not neurotoxic, pre-treatment-but not concurrent or post-treatment-with this cytokine potentiated neuronal injury induced by depriving cultures of either oxygen, glucose, or both oxygen and glucose. Cytotoxicity was abolished by an IL-1β-neutralizing antibody. Together, these results demonstrate the establishment of reliable and reproducible in vitro models that will now allow detailed investigation of the cellular and molecular mechanisms relating to IL-1β-mediated neuronal cell death.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 161, Issues 1â2, April 2005, Pages 93-100
Journal: Journal of Neuroimmunology - Volume 161, Issues 1â2, April 2005, Pages 93-100
نویسندگان
Birgit Fogal, James A. Hewett, Sandra J. Hewett,