کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9194567 | 1580504 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pro-inflammatory cytokines modify neuronal nicotinic acetylcholine receptor assembly
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Pro-inflammatory cytokines modify neuronal nicotinic acetylcholine receptor assembly Pro-inflammatory cytokines modify neuronal nicotinic acetylcholine receptor assembly](/preview/png/9194567.png)
چکیده انگلیسی
We have examined the impact of the inflammatory cytokines interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNFα) on assembly of nAChRs from subunit mixtures of nAChRα4, β2 and β4 transiently transfected into 293 cells. In control transfections approximately 55% of α4 associated preferentially with β4, but less than 15% complexed with β2 and the remainder was associated with both β subunits. These relative ratios were modified by pro-inflammatory cytokines. IL-1β strongly enhanced α4/β2 association and decreased α4/β4, whereas TNFα promoted mixed α4/β2/β4 interactions. These results show that the emerging rules governing assembly of nAChRs are subject to modification by the pro-inflammatory cytokine environment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 166, Issues 1â2, September 2005, Pages 88-101
Journal: Journal of Neuroimmunology - Volume 166, Issues 1â2, September 2005, Pages 88-101
نویسندگان
Lorise C. Gahring, Emily L. Days, Tuesday Kaasch, Mónica González de Mendoza, Leah Owen, Karina Persiyanov, Scott W. Rogers,