کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9194584 | 1580503 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antigen-induced suppressor T cells from the skin point of view
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
The rebirth of interest in suppressor T cells has spawned a vast amount of data that shed light on their biology and role in immune system homeostasis. Since the early studies on the naturally occurring CD4+Â /Â CD25+ T regulatory cells, much attention has been focused on ways to induce suppressor T cells in vivo. This review discusses the salient features of the induction of antigen-specific suppressor T cells in a T cell receptor (TCR) transgenic mouse model of experimental allergic encephalomyelitis (EAE) in response to epicutaneous immunization with cognate peptide. We discuss the skin environment as a privileged anatomical site for therapeutic intervention against pro-inflammatory auto-immune disorders using non-invasive approaches for antigen delivery.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 167, Issues 1â2, October 2005, Pages 4-12
Journal: Journal of Neuroimmunology - Volume 167, Issues 1â2, October 2005, Pages 4-12
نویسندگان
Margaret S. Bynoe, Christophe Viret,