کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9194597 | 1580503 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The glycopeptide CSF114(Glc) detects serum antibodies in multiple sclerosis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Synthetic glycopeptides have the potential to detect antibodies in multiple sclerosis (MS). In the present study, we analyzed the antibodies (IgM class, IgG class and IgG subclasses) to the synthetic glycopeptide CSF114(Glc) in the serum of 186 MS patients, 166 blood donors (BDs), 25 patients affected by meningitis/encephalitis, 41 affected by systemic lupus erythematosus (SLE) and 49 affected by rheumatoid arthritis (RA). The IgM antibody level to CSF114(Glc) was significantly increased in MS patients versus BDs (p < 0.001) or versus other autoimmune diseases (SLE or RA, p < 0.001). The IgG response was restricted to the subclass IgG2. IgM antibodies to CSF114(Glc) were found in 30% of relapsing/remitting MS patients and, at lower levels, in subjects affected by meningitis/encephalitis. The study of antibodies to CSF114(Glc) is a new, potential immunological marker of MS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 167, Issues 1â2, October 2005, Pages 131-137
Journal: Journal of Neuroimmunology - Volume 167, Issues 1â2, October 2005, Pages 131-137
نویسندگان
Francesco Lolli, Benedetta Mazzanti, Marta Pazzagli, Elisa Peroni, Maria Claudia Alcaro, Giuseppina Sabatino, Roberta Lanzillo, Vincenzo Brescia Morra, Lucio Santoro, Claudio Gasperini, Stefania Galgani, Mario Milco D'Elios, Valentina Zipoli,