کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9194625 1580510 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Circadian responses to endotoxin treatment in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Circadian responses to endotoxin treatment in mice
چکیده انگلیسی
We tested the ability of Escherichia coli lipopolysaccharide (LPS) to phase-shift the activity circadian rhythm in C57Bl/6J mice. Intraperitoneal administration of 25 μg/kg LPS induced photic-like phase delays (−43±10 min) during the early subjective night. These delays were non-additive to those induced by light at CT 15, and were reduced by the previous administration of sulfasalazine, a NF-κB activation inhibitor. At CT 15, LPS induced c-Fos expression in the dorsal area of the suprachiasmatic nuclei (SCN). Our results suggest that the activation of the immune system should be considered an entraining signal for the murine circadian clock.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 160, Issues 1–2, March 2005, Pages 102-109
نویسندگان
, , , ,