کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9194703 1580505 2005 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Autoimmune tolerance eliminates relapses but fails to halt progression in a model of multiple sclerosis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Autoimmune tolerance eliminates relapses but fails to halt progression in a model of multiple sclerosis
چکیده انگلیسی
To date there has been poor translation of immunotherapies from rodent models to treatment of progressive multiple sclerosis (MS). In the robust, relapsing Biozzi ABH mouse model of MS, using a combination of a transient deletion of T cells followed by intravenous (i.v.) myelin antigen administration, established relapsing disease in EAE can be effectively silenced. However, when treatment was initiated in late stage chronic-relapsing disease, despite inhibition of further relapses, mice demonstrated evidence of disease progression shown by a deterioration in mobility and development of spasticity and indicates that targeting relapsing, immunological components of MS alone is unlikely to be sufficient to control progression in the late stages of MS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 165, Issues 1–2, August 2005, Pages 41-52
نویسندگان
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