کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9194705 | 1580505 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
IL-10 plays a vital role in controlling the inflammatory response during acute Toxoplasma gondii infection, however the production of IL-10 during the chronic phase of toxoplasmosis has been associated with parasite persistence. To address this paradox, the production and effect of IL-10 in the brain during toxoplasmic encephalitis (TE) was investigated. Analysis of brain mononuclear cells (BMNC) from chronically infected mice revealed that infiltrating macrophages and CD4+ T cells were the major sources of IL-10. Endogenous levels of IL-10 inhibited the production of IL-12, IFN-γ, TNF-α, and IL-6 from both hematopoetic and non-hematopoetic cells in the brain, as well as anti-microbial activity of astrocytes. Furthermore, IL-10-/- mice that progressed to the chronic phase of infection had equivalent parasite burden to WT mice but developed a lethal inflammatory response within the brain characterized by increased numbers of CD4+ T cells and macrophages, and elevated production of inflammatory cytokines. Finally, partial depletion of CD4+ T cells decreased the severity of the inflammation in the brain and allowed IL-10-/- mice to survive infection. Together these results point to a vital role for IL-10 in the control of CD4+ T cell mediated inflammation in the brain during TE.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 165, Issues 1â2, August 2005, Pages 63-74
Journal: Journal of Neuroimmunology - Volume 165, Issues 1â2, August 2005, Pages 63-74
نویسندگان
Emma H. Wilson, Ulrike Wille-Reece, Florence Dzierszinski, Christopher A. Hunter,