کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9194711 1580505 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anti-TNF-α reduces the inflammatory reaction associated with cuff electrode implantation around the sciatic nerve
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Anti-TNF-α reduces the inflammatory reaction associated with cuff electrode implantation around the sciatic nerve
چکیده انگلیسی
Extraneural cuff electrodes have been extensively used to investigate the nervous system. Their implantation is, however, associated with epineurial fibrosis, fiber loss, limited reproducibility of recordings and variability in stimulating conditions. It has recently been shown that TNF-α is involved in nerve alterations after electrode implantation. This study investigated whether a peri-operative anti-TNF-α treatment could modify the inflammation and fibrosis associated with cuff electrode implantation. Morphometrical and immunohistochemical methods were used to show that a single systemic injection of TNF-α neutralizing antibodies is sufficient to reduce the early inflammatory events, but not the long lasting fibrotic reaction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 165, Issues 1–2, August 2005, Pages 121-128
نویسندگان
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