کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9194711 | 1580505 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anti-TNF-α reduces the inflammatory reaction associated with cuff electrode implantation around the sciatic nerve
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Extraneural cuff electrodes have been extensively used to investigate the nervous system. Their implantation is, however, associated with epineurial fibrosis, fiber loss, limited reproducibility of recordings and variability in stimulating conditions. It has recently been shown that TNF-α is involved in nerve alterations after electrode implantation. This study investigated whether a peri-operative anti-TNF-α treatment could modify the inflammation and fibrosis associated with cuff electrode implantation. Morphometrical and immunohistochemical methods were used to show that a single systemic injection of TNF-α neutralizing antibodies is sufficient to reduce the early inflammatory events, but not the long lasting fibrotic reaction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 165, Issues 1â2, August 2005, Pages 121-128
Journal: Journal of Neuroimmunology - Volume 165, Issues 1â2, August 2005, Pages 121-128
نویسندگان
Valérie Vince, MÃ¥rten E. Brelen, Jean Delbeke, Ides M. Colin,