کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9194712 | 1580505 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Thermal injury and sepsis modulates β-adrenergic receptors and cAMP reponses in monocyte-committed bone marrow cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Thermal injury and sepsis modulates β-adrenergic receptors and cAMP reponses in monocyte-committed bone marrow cells Thermal injury and sepsis modulates β-adrenergic receptors and cAMP reponses in monocyte-committed bone marrow cells](/preview/png/9194712.png)
چکیده انگلیسی
We have previously reported that adrenergic stimulation enhances monocytopoiesis following experimental burn injury and sepsis (BI/S). In the present work we measured β-adrenergic receptor number and affinity in bone marrow committed monocyte progenitor cells (CD59+) following BI/S. We find that BI/S treatment significantly decreased monocyte progenitor cell β-adrenergic receptors but significantly increased receptor binding affinity and isoproterenol-stimulated cAMP production. CD14 expression in macrophages derived in vitro from CD59+ cells following BI/S was significantly increased by epinephrine and this change was blocked by β2-adrenergic receptor antagonist. PCR analysis suggests the presence of β2- but not β1-adrenergic receptors. Enhanced adrenergic receptor signaling in CD59+ bone marrow cells following BI/S may be important in macrophage development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 165, Issues 1â2, August 2005, Pages 129-138
Journal: Journal of Neuroimmunology - Volume 165, Issues 1â2, August 2005, Pages 129-138
نویسندگان
Kuzhali Muthu, Jiangping Deng, Fred Romano, L.-K. He, Richard Gamelli, Ravi Shankar, Stephen B. Jones,