کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9194821 | 1580512 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The febrile response to intraperitoneal lipopolysaccharide: strain and gender differences in rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The febrile response to intraperitoneal lipopolysaccharide: strain and gender differences in rats The febrile response to intraperitoneal lipopolysaccharide: strain and gender differences in rats](/preview/png/9194821.png)
چکیده انگلیسی
The acute-phase febrile responses of the inbred Lewis (LEW) and Fischer 344 (F344) rat strains and their parent Sprague-Dawley (S-D) strain to immune challenge with lipopolysaccharide (LPS) were compared. LEW and S-D males and females displayed a biphasic febrile response with a markedly attenuated second phase in F344 rats. At 2 h after LPS (50 μg/kg), corticosterone was significantly higher in F344 than in LEW rats, but serum interleukin-1β was higher only in F344 than LEW males. These data suggest that the greater LPS-induced corticosterone response of F344 rats mediates differences between febrile responses of F344 and LEW males and females.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 158, Issues 1â2, January 2005, Pages 86-93
Journal: Journal of Neuroimmunology - Volume 158, Issues 1â2, January 2005, Pages 86-93
نویسندگان
Anna N. Taylor, Delia L. Tio, Horacio E. Romeo,