کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9197841 1188876 2005 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Unified SPM-ICA for fMRI analysis
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
Unified SPM-ICA for fMRI analysis
چکیده انگلیسی
A widely used tool for functional magnetic resonance imaging (fMRI) data analysis, statistical parametric mapping (SPM), is based on the general linear model (GLM). SPM therefore requires a priori knowledge or specific assumptions about the time courses contributing to signal changes. In contradistinction, independent component analysis (ICA) is a data-driven method based on the assumption that the causes of responses are statistically independent. Here we describe a unified method, which combines ICA, temporal ICA (tICA), and SPM for analyzing fMRI data. tICA was applied to fMRI datasets to disclose independent components, whose number was determined by the Bayesian information criterion (BIC). The resulting components were used to construct the design matrix of a GLM. Parameters were estimated and regionally-specific statistical inferences were made about activations in the usual way. The sensitivity and specificity were evaluated using Monte Carlo simulations. The receiver operating characteristic (ROC) curves indicated that the unified SPM-ICA method had a better performance. Moreover, SPM-ICA was applied to fMRI datasets from twelve normal subjects performing left and right hand movements. The areas identified corresponded to motor (premotor, sensorimotor areas and SMA) areas and were consistently task related. Part of the frontal lobe, parietal cortex, and cingulate gyrus also showed transiently task-related responses. The unified method requires less supervision than the conventional SPM and enables classical inference about the expression of independent components. Our results also suggest that the method has a higher sensitivity than SPM analyses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 25, Issue 3, 15 April 2005, Pages 746-755
نویسندگان
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