کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9197911 1188879 2005 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Absolute CBF and CBV measurements by MRI bolus tracking before and after acetazolamide challenge: Repeatabilily and comparison with PET in humans
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
Absolute CBF and CBV measurements by MRI bolus tracking before and after acetazolamide challenge: Repeatabilily and comparison with PET in humans
چکیده انگلیسی
Bolus tracking magnetic resonance imaging (MRI) is a powerful technique for assessing cerebral perfusion, but its capability to measure absolute cerebral blood flow (CBF) and volume (CBV) values is still debated. To validate the MRI technique, absolute CBF and CBV values in healthy humans obtained by echo planar gradient echo MRI were compared to H215O and 11CO positron emission tomography (PET) before and after acetazolamide (ACZ) (n = 8) or saline (n = 4) administration. The repeatability of CBF and CBV measurements was moderate with both methods, and slightly lower with MRI than with PET. At rest, the mean CBF values were similar with both techniques except in the cortex where they were moderately higher with MRI. CBV was higher with MRI than with PET in all areas, which may reflect an underestimation of the arterial input function (AIF). After ACZ, a significant CBF increase was observed in gray matter with both MRI and PET, suggesting that MRI might be used to assess the cerebrovascular reserve. In individual subjects, the correlation between MRI and PET measurements was good for both CBF and CBV (R2 between 0.70 and 0.84). However, when all results were considered as a group, R2 was lower (0.40 to 0.65), and the limits of agreement between the two methods (SD of the difference) were large. Our data suggest that physiologic CBF values and systematically overestimated CBV values may be obtained with MRI in healthy humans, but that an individual scale factor should be applied to MRI measurements to improve the agreement with PET.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 26, Issue 2, June 2005, Pages 525-535
نویسندگان
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