کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9198054 1188886 2005 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cortical thickness analysis in autism with heat kernel smoothing
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
Cortical thickness analysis in autism with heat kernel smoothing
چکیده انگلیسی
We present a novel data smoothing and analysis framework for cortical thickness data defined on the brain cortical manifold. Gaussian kernel smoothing, which weights neighboring observations according to their 3D Euclidean distance, has been widely used in 3D brain images to increase the signal-to-noise ratio. When the observations lie on a convoluted brain surface, however, it is more natural to assign the weights based on the geodesic distance along the surface. We therefore develop a framework for geodesic distance-based kernel smoothing and statistical analysis on the cortical manifolds. As an illustration, we apply our methods in detecting the regions of abnormal cortical thickness in 16 high functioning autistic children via random field based multiple comparison correction that utilizes the new smoothing technique.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 25, Issue 4, 1 May 2005, Pages 1256-1265
نویسندگان
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