کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9200848 | 1189417 | 2005 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The differential gene expression profiles of proximal and distal muscle groups are altered in pre-pathological dysferlin-deficient mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب تکاملی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The differential gene expression profiles of proximal and distal muscle groups are altered in pre-pathological dysferlin-deficient mice The differential gene expression profiles of proximal and distal muscle groups are altered in pre-pathological dysferlin-deficient mice](/preview/png/9200848.png)
چکیده انگلیسی
The selective pattern of muscle involvement is a key feature of muscular dystrophies. Dysferlinopathy is a good model for studying this process since it shows variable muscle involvement that can be highly selective even in individual patients. The transcriptomes of proximal and distal muscles from wildtype C57BL/10 and dysferlin deficient C57BL/10.SJL-Dysf mice at a prepathological stage were assessed using the Affymetrix oligonucleotide-microarray system. We detected significant variation in gene expression between proximal and distal muscle in wildtype mice. Dysferlin defiency, even in the absence of pathological changes, altered this proximal distal difference but with little specific overlap with previous microarray analyses of dysferlinopathy. In conclusion, proximal and distal muscle groups show distinct patterns of gene expression and respond differently to dysferlin deficiency. This has implications for the selection of muscles for future microarray analyses, and also offers new routes for investigating the selectivity of muscle involvement in muscular dystrophies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuromuscular Disorders - Volume 15, Issue 12, December 2005, Pages 863-877
Journal: Neuromuscular Disorders - Volume 15, Issue 12, December 2005, Pages 863-877
نویسندگان
Maja von der Hagen, Steven H. Laval, Lynsey M. Cree, Faye Haldane, Matthew Pocock, Ilka Wappler, Heiko Peters, Herbert A. Reitsamer, Harald Hoger, Maria Wiedner, Felicitas Oberndorfer, Louise V.B. Anderson, Volker Straub, Reginald E. Bittner,