کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9200917 | 1189422 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
ADAM12 overexpression does not improve outcome in mice with laminin α2-deficient muscular dystrophy
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب تکاملی
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![عکس صفحه اول مقاله: ADAM12 overexpression does not improve outcome in mice with laminin α2-deficient muscular dystrophy ADAM12 overexpression does not improve outcome in mice with laminin α2-deficient muscular dystrophy](/preview/png/9200917.png)
چکیده انگلیسی
We have recently shown that overexpression of ADAM12 results in increased muscle regeneration and significantly reduced pathology in mdx, dystrophin deficient mice. In the present study, we tested the effect of overexpressing ADAM12 in dyW laminin-deficient mice. dy mice have a very severe clinical phenotype and would be expected to benefit greatly from enhanced regeneration. We found that dyW mice overexpressing ADAM12 indeed have increased muscle regeneration, as evidenced by increased numbers of muscle fibers expressing fetal myosin. However, overexpression of ADAM12 had no significant effect on overall health, as evidenced by body weight, and did not improve muscle pathology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuromuscular Disorders - Volume 15, Issue 11, November 2005, Pages 786-789
Journal: Neuromuscular Disorders - Volume 15, Issue 11, November 2005, Pages 786-789
نویسندگان
Ling T. Guo, G. Diane Shelton, Ulla M. Wewer, Eva Engvall,