کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9207261 | 1191711 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of acute alcohol ingestion prior to burn injury on intestinal bacterial growth and barrier function
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
مراقبت های ویژه و مراقبتهای ویژه پزشکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effect of acute alcohol ingestion prior to burn injury on intestinal bacterial growth and barrier function Effect of acute alcohol ingestion prior to burn injury on intestinal bacterial growth and barrier function](/preview/png/9207261.png)
چکیده انگلیسی
Previous studies from our laboratory have shown that acute alcohol (EtOH) ingestion prior to burn injury enhances intestinal bacterial translocation. This study tested if increased intestinal bacterial translocation in alcohol and burn injured rats is due to an overgrowth in intestinal bacteria. We determined if the translocation was accompanied with alterations in intestinal permeability and immune cell population. Rats (225-250 g) were gavaged with alcohol to achieve a blood EtOH level in the range of 100 mg/dl prior to burn or sham injury (25% total body surface area). Two days after injury, we found that acute alcohol ingestions prior to burn injury results in a significant increase in bacterial counts in small intestine. The increase in intestinal bacterial counts accompanied a significant increase in intestinal permeability. Finally, immunohistochemical analysis revealed a substantial (p < 0.05) loss of both T cell and dendritic cells in intestine of alcohol and burn injured rats compared with intestine of rats receiving either burn or sham injury. Altogether, results presented in this manuscript suggest that increase in intestinal bacterial growth along with alterations in intestinal permeability and immune status contribute to the increase in bacterial translocation observed in alcohol and burn injured rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Burns - Volume 31, Issue 3, May 2005, Pages 290-296
Journal: Burns - Volume 31, Issue 3, May 2005, Pages 290-296
نویسندگان
Michael J. Kavanaugh, Charles Clark, Masakatsu Goto, Elizabeth J. Kovacs, Richard L. Gamelli, Mohammed M. Sayeed, Mashkoor A. Choudhry,