Neural correlates of attention bias to threat in post-traumatic stress disorder

Attentional biases have been proposed to contribute to symptom maintenance in posttraumatic stress disorder (PTSD), although the neural correlates of these processes have not been well defined; this was the goal of the present study. We administered an attention bias task, the dot probe, to a sample of 37 (19 control, 18 PTSD+) traumatized African-American adults during fMRI. Compared to controls, PTSD+ participants demonstrated increased activation in the dorsolateral prefrontal cortex (dlPFC) in response to threat cue trials. In addition, attentional avoidance of threat corresponded with increased ventrolateral prefrontal cortex (vlPFC) and dorsal anterior cingulate cortex (dACC) activation in the PTSD group, a pattern that was not observed in controls. These data provide evidence to suggest that relative increases in dlPFC, dACC and vlPFC activation represent neural markers of attentional bias for threat in individuals with PTSD, reflecting selective disruptions in attentional control and emotion processing networks in this disorder.

► Behavioral and neuroimaging methods were combined to examine attention bias in a traumatized sample.
► PTSD+ individuals demonstrated increased activation to threat in a cognitive control brain region.
► Threat cue avoidance corresponded with increased activation in an emotion processing region in PTSD.
► Disproportional allocation of cognitive control resources to trauma cues may perpetuate PTSD.