کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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921453 | 920777 | 2010 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Emotional management and 5-HT2A receptor gene variance in patients with schizophrenia Emotional management and 5-HT2A receptor gene variance in patients with schizophrenia](/preview/png/921453.png)
Individuals with schizophrenia exhibit impaired social cognitive functions, particularly emotion management. Emotion management may be partially regulated by the serotoninergic system; the −1438 A/G polymorphism in the promoter region of the 5-HT2A gene can modulate 5-HT2A activity and is linked to certain emotional traits and anger- and aggression-related behaviors. The current study aimed to investigate whether this 5-HT2A genetic variance is associated with social cognitive function, particularly the management of emotions. One hundred and fifteen patients with chronic schizophrenia were stabilized with an optimal-dose of antipsychotic treatment. All were genotyped for the −1438 A/G polymorphism and assessed with symptom rating scales, neurocognitive instruments, and the “Managing Emotions” section of Mayer–Salovey–Caruso Emotional Intelligence Test (MSCEIT). Multiple regression showed that patients with the A/G genotype performed better than those with G/G in managing emotion (p = 0.018) but did not differ from those with the A/A genotype. Regarding the two subtasks of the Managing Emotions section, the A/G heterozygotes also performed better than the G/G homozygotes in the emotion management (p = 0.026) and emotional relations (p = 0.027) subtasks. The results suggest that variability in the 5-HT2A gene may influence emotion management in patients with schizophrenia.
Journal: Biological Psychology - Volume 83, Issue 2, February 2010, Pages 79–83