Treatment with IFN-γ increases serum levels of Th1 chemokines and decreases those of Th2 chemokines in patients with mycosis fungoides

In IFN-γ treatment as well as other therapies, TARC may serve as a marker for the disease activity of mycosis fungoides. The dramatic elevation of MIG by IFN-γ suggests the strong dependency of MIG production on IFN-γ and the participation of MIG in skin-infiltration of tumoricidal cytotoxic T cells.