کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9244068 | 1209899 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Corticotropin-Releasing Hormone Receptor 1 Antagonist Blocks Brain-Gut Activation Induced by Colonic Distention in Rats
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کلمات کلیدی
CRHIC50EPMIBSlocus ceruleuselevated plus maze - بالا به همراه پیچ و خمirritable bowel syndrome - سندروم روده تحریک پذیر، کولیت عصبیmedian inhibitory concentration - غلظت بازدارنده متوسطPVN - مالیات بر ارزش افزودهparaventricular nucleus - هسته پروژسترویکcorticotropin-releasing hormone - هورمون آزاد کننده کورتیکوتروپینHPLC - کروماتوگرافی مایعی کاراhigh-performance liquid chromatography - کروماتوگرافی مایعی کاراCRH receptor - گیرنده CRH
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Corticotropin-Releasing Hormone Receptor 1 Antagonist Blocks Brain-Gut Activation Induced by Colonic Distention in Rats Corticotropin-Releasing Hormone Receptor 1 Antagonist Blocks Brain-Gut Activation Induced by Colonic Distention in Rats](/preview/png/9244068.png)
چکیده انگلیسی
Background & Aims: The corticotropin-releasing hormone receptor 1 mediates stress-induced changes in colonic motor activity and emotion. We tested the hypothesis that pretreatment with JTC-017, a specific corticotropin-releasing hormone receptor 1 antagonist, blocks colorectal distention-induced hippocampal noradrenaline release and visceral perception in rats. We also investigated whether pretreatment with JTC-017 blocks acute or chronic colorectal distention-induced adrenocorticotropic hormone release, anxiety, and stress-induced changes in colonic motility. Methods: Rats were pretreated intrahippocampally with α-helical corticotropin-releasing hormone (1.25 μg/kg; vehicle), a nonspecific corticotropin-releasing hormone receptor antagonist, or intraperitoneally with JTC-017 (10 mg/kg). Hippocampal noradrenaline release after microdialysis and the frequency of abdominal contractions were measured in response to acute colorectal distention. Plasma adrenocorticotropic hormone levels, anxiety-related behavior, and stress-induced changes in colonic motility were evaluated after acute or chronic colorectal distention followed by exposure to an elevated plus maze. Results: Administration of α-helical corticotropin-releasing hormone or JTC-017 significantly attenuated hippocampal noradrenaline release and reduced the frequency of abdominal contractions induced by acute distention. In addition, JTC-017 significantly reduced plasma adrenocorticotropic hormone and anxiety after acute distention. After chronic distention, changes in plasma adrenocorticotropic hormone and anxiety were not significant because of habituation. In contrast, a significant increase in fecal pellet output during the elevated plus maze was observed after chronic distention. This increase in fecal pellet output was blocked by pretreatment with JTC-017. Conclusions: Our results suggest that JTC-017, a specific corticotropin-releasing hormone receptor 1 antagonist, attenuates hippocampal noradrenaline release, visceral perception, adrenocorticotropic hormone release, and anxiety after acute colorectal distention in rats. In addition, JTC-017 blocks stress-induced changes in colonic motility after chronic colorectal distention in rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 129, Issue 5, November 2005, Pages 1533-1543
Journal: Gastroenterology - Volume 129, Issue 5, November 2005, Pages 1533-1543
نویسندگان
Kumi Saito, Toshiyuki Kasai, Yohko Nagura, Hitomi Ito, Motoyori Kanazawa, Shin Fukudo,