Impact of negative affectively charged stimuli and response style on cognitive-control-related neural activation: An ERP study

• AX-CPT paradigm was administered with neutral and negative IAPS pictures.
• N2 (ERP) and LORETA (source space) activation was measured.
• Behavior shift index (BSI), measure of response style, was computed.
• A proactive style of responding related to less PFC activation while planning action strategies.
• A reactive style of responding related to less PFC activation while adjusting action strategies.

The canonical AX-CPT task measures two forms of cognitive control: sustained goal-oriented control (“proactive” control) and transient changes in cognitive control following unexpected events (“reactive” control). We modified this task by adding negative and neutral International Affective Picture System (IAPS) pictures to assess the effects of negative emotion on these two forms of cognitive control. Proactive and reactive control styles were assessed based on measures of behavior and electrophysiology, including the N2 event-related potential component and source space activation (Low Resolution Tomography [LORETA]). We found slower reaction-times and greater DLPFC activation for negative relative to neutral stimuli. Additionally, we found that a proactive style of responding was related to less prefrontal activation (interpreted to reflect increased efficiency of processing) during actively maintained previously cued information and that a reactive style of responding was related to less prefrontal activation (interpreted to reflect increased efficiency of processing) during just-in-time environmentally triggered information. This pattern of results was evident in relatively neutral contexts, but in the face of negative emotion, these associations were not found, suggesting potential response style-by-emotion interaction effects on prefrontal neural activation.