کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9252742 1210868 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genipin prevents fulminant hepatic failure resulting in reduction of lethality through the suppression of TNF-α production
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Genipin prevents fulminant hepatic failure resulting in reduction of lethality through the suppression of TNF-α production
چکیده انگلیسی
Genipin is a metabolite derived from the herbal medicine Inchinko-to. Little is known about the mechanism of genipin action on acute liver injury through inflammatory cytokines. We examined the effects of genipin on production of TNF-α in vivo and in vitro. Mice were given GalN/LPS with or without genipin treatment. All mice not given genipin died within 12 h. But in mice given genipin, 8 of 15 mice survived for 24 h after GalN/LPS administration. Histologically, hepatic necrosis and inflammatory cells infiltration were significantly slight in mice given genipin. Serum AST and ALT activity were significantly lower in mice given genipin. Serum and liver homogenate TNF-α levels were significantly lower in mice given genipin. However, in IL-6 and IL-1β, there were no significant differences in mice given and not given genipin. TNF-α, NF-κB activation and TNF-α mRNA expression in a cultured mouse macrophage-like cell line J774.1 were significantly suppressed by genipin administration. In conclusion, the present findings suggest that genipin, a metabolite derived form the herbal medicine Inchinko-to improved acute liver dysfunction by suppressive effect of TNF-α production.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hepatology Research - Volume 33, Issue 4, December 2005, Pages 298-305
نویسندگان
, , , , , , , , , , , , , , ,