کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9252773 1210871 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Thiazolidinediones: Pleiotropic drugs with potent anti-inflammatory properties for tissue protection
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Thiazolidinediones: Pleiotropic drugs with potent anti-inflammatory properties for tissue protection
چکیده انگلیسی
In conclusion, TZDs are important new drugs, presently indicated for the treatment of type 2 diabetes but with a spectrum of properties which suggests their potential for treating a number of degenerative inflammatory diseases, including NASH. However, full-scale, long-term clinical trials are needed with TZDs to test their potential to treat NASH, not least because of the (hepatotoxic) legacy of the prototype TZD, troglitazone, but also in view of the escalating burden of liver disease which is accompanying the increasing global prevalence of clinical obesity and type 2 diabetes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hepatology Research - Volume 33, Issue 2, October 2005, Pages 167-170
نویسندگان
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