Auditory–prefrontal axonal connectivity in the macaque cortex: Quantitative assessment of processing streams

• Two comprehensive auditory–prefrontal networks are acquired by means of systematic data collation and literature analysis.
• Efficient quantitative procedure for assessing auditory processing streams is provided.
• Implications for neurobiology of language are discussed.
• Preliminary analyses include parietal structures as well.

Primate sensory systems subserve complex neurocomputational functions. Consequently, these systems are organised anatomically in a distributed fashion, commonly linking areas to form specialised processing streams. Each stream is related to a specific function, as evidenced from studies of the visual cortex, which features rather prominent segregation into spatial and non-spatial domains. It has been hypothesised that other sensory systems, including auditory, are organised in a similar way on the cortical level. Recent studies offer rich qualitative evidence for the dual stream hypothesis. Here we provide a new paradigm to quantitatively uncover these patterns in the auditory system, based on an analysis of multiple anatomical studies using multivariate techniques. As a test case, we also apply our assessment techniques to more ubiquitously-explored visual system. Importantly, the introduced framework opens the possibility for these techniques to be applied to other neural systems featuring a dichotomised organisation, such as language or music perception.