کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
925365 921485 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Changes in N400 topography following intensive speech language therapy for individuals with aphasia
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Changes in N400 topography following intensive speech language therapy for individuals with aphasia
چکیده انگلیسی

Our goal was to characterize the effects of intensive aphasia therapy on the N400, an electrophysiological index of lexical-semantic processing. Immediately before and after 4 weeks of intensive speech-language therapy, people with aphasia performed a task in which they had to determine whether spoken words were a ‘match’ or a ‘mismatch’ to pictures of objects. Pre-therapy, people with aphasia exhibited an N400 mismatch effect that started over right hemisphere electrodes. Post-therapy, gains were seen in clinical measures of language ability, and the onset of the N400 was left-lateralized. No changes in the scalp distribution of the N400 were observed in healthy controls tested twice over the same 4 week interval. Since the distribution of the N400 after aphasia therapy differed from that of healthy controls, we conclude that it reflects the engagement of compensatory neural mechanisms for language processing rather than a return to a “normal” pattern of brain activation.


► Investigated the N400, an index of lexical processing, in people with aphasia.
► The N400 was more left lateralized after intensive speech-language therapy.
► We suggest this reflects compensatory processing associated with therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain and Language - Volume 123, Issue 2, November 2012, Pages 94–103
نویسندگان
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