کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9256139 | 1590365 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Diagnostic criteria in predicting a biliary origin of acute pancreatitis in the era of endoscopic ultrasound: Multicentre prospective evaluation of 213 patients
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Diagnostic criteria in predicting a biliary origin of acute pancreatitis in the era of endoscopic ultrasound: Multicentre prospective evaluation of 213 patients Diagnostic criteria in predicting a biliary origin of acute pancreatitis in the era of endoscopic ultrasound: Multicentre prospective evaluation of 213 patients](/preview/png/9256139.png)
چکیده انگلیسی
Background: No study on bioclinical criteria predicting a biliary origin for acute pancreatitis has included endosonography as a reference examination. Re-examination of bioclinical parameters deserves consideration in the era where other causes are known (e.g. hereditary, autoimmune). Aim and Methods: To determine the performance of bioclinical markers in predicting a biliary origin of acute pancreatitis where the diagnosis of biliary lithiasis was established or ruled out using endosonography. Only patients with a first acute episode of pancreatitis were included. Results: 213 patients (male: 55%; median age: 56 years) were prospectively included in 14 centres. Causes of acute pancreatitis were: biliary (62%), alcoholic (25%), other (13%). Delay between symptom-onset and admission was <48 h in 80%. Endosonography was the sole method establishing the diagnosis of biliary pancreatitis in 15% of patients. At univariate analysis, age, female sex, declared alcohol consumption, elevated aspartate and alanine transaminases on admission, gammaglutamyl transferase, alkaline phosphatase, total bilirubin, lipase, mean corpuscular volume were predictive of a biliary origin. Only age (p < 0.0001), sex (p < 0.0008) and alanine transaminase (p < 0.0004) remained significant at multivariate analysis. At age 50, the respective sensitivity and specificity were 73 and 65%. With an elevated alanine transaminase at 2 times the upper limit of normal range, the respective sensitivity and specificity were 74 and 84%. The probability of a biliary origin of acute pancreatitis could be estimated by the following formula: = 1/1 + exp(4.6967 â 0.0656 Ã age + 1.1208 Ã sex â 0.6909 Ã alanine transaminase). Conclusion: When endosonography is performed to confirm or exclude a biliary origin of acute pancreatitis, age, sex and alanine transaminase at admission are the only factors predictive of a biliary cause.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pancreatology - Volume 5, Issues 4â5, 2005, Pages 450-456
Journal: Pancreatology - Volume 5, Issues 4â5, 2005, Pages 450-456
نویسندگان
Philippe Lévy, Arnaud Boruchowicz, Patrick Hastier, Alexandre Pariente, Thierry Thévenot, Jean Louis Frossard, Louis Buscail, François Mauvais, Jean Claude Duchmann, Alain Courrier, Philippe Bulois, Jean Louis Gineston, Marc Barthet, Henri Licht,