کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9256194 1590366 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vitro effects of intravenous anesthetics on the sphincter of oddi strips of sheep
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
In vitro effects of intravenous anesthetics on the sphincter of oddi strips of sheep
چکیده انگلیسی
Background: Intravenous anesthetics are often used for conscious sedation in endoscopic retrograde cholangio-pancreatography (ERCP) and endoscopic sphincter of Oddi (SO) manometry. This study was designed to investigate the direct effects of some intravenous anesthetics on SO in sheep. Methods: In sheep SO rings, changes in isometric tension in response to cumulative concentrations of intravenous anesthetics were determined, and values for Emax (mean maximal inhibition) and pD2 (i.e. the negative logarithm of the concentration for the half-maximal response, EC50) were compared. Results: Meperidine (10−7 to 3 × 10−5M), fentanyl (10−7 to 3 × 10−5M), midazolam (10−7 to 3 × 10−5M) and propofol (10−7 to 3 × 10−4M) induced concentration-dependent relaxations on SO precontracted with carbachol (10−6M). Emax and pD2 values following meperidine, fentanyl and midazolam administration were significantly greater than after propofol (p < 0.05). There were no significant differences in Emax and pD2 values for meperidine, fentanyl and midazolam. Conclusion: These results suggest that meperidine, fentanyl and midazolam are equipotent relaxants in the sheep SO in vitro. The relaxatory effect of propofol was 10 times less potent compared to the above agents, and it can be beneficial during SO manometry in controlled clinical human studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pancreatology - Volume 5, Issues 2–3, 2005, Pages 215-219
نویسندگان
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