کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9256194 | 1590366 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro effects of intravenous anesthetics on the sphincter of oddi strips of sheep
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Background: Intravenous anesthetics are often used for conscious sedation in endoscopic retrograde cholangio-pancreatography (ERCP) and endoscopic sphincter of Oddi (SO) manometry. This study was designed to investigate the direct effects of some intravenous anesthetics on SO in sheep. Methods: In sheep SO rings, changes in isometric tension in response to cumulative concentrations of intravenous anesthetics were determined, and values for Emax (mean maximal inhibition) and pD2 (i.e. the negative logarithm of the concentration for the half-maximal response, EC50) were compared. Results: Meperidine (10â7 to 3 Ã 10â5M), fentanyl (10â7 to 3 Ã 10â5M), midazolam (10â7 to 3 Ã 10â5M) and propofol (10â7 to 3 Ã 10â4M) induced concentration-dependent relaxations on SO precontracted with carbachol (10â6M). Emax and pD2 values following meperidine, fentanyl and midazolam administration were significantly greater than after propofol (p < 0.05). There were no significant differences in Emax and pD2 values for meperidine, fentanyl and midazolam. Conclusion: These results suggest that meperidine, fentanyl and midazolam are equipotent relaxants in the sheep SO in vitro. The relaxatory effect of propofol was 10 times less potent compared to the above agents, and it can be beneficial during SO manometry in controlled clinical human studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pancreatology - Volume 5, Issues 2â3, 2005, Pages 215-219
Journal: Pancreatology - Volume 5, Issues 2â3, 2005, Pages 215-219
نویسندگان
Mustafa Turan, Ihsan Bagcivan, Sinan Gursoy, Bulent Sarac, Mustafa Duman, Tijen Kaya,