کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9298732 | 1244974 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Adiponectina: un nuevo nexo entre obesidad, resistencia a la insulina y enfermedad cardiovascular
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Adiponectina: un nuevo nexo entre obesidad, resistencia a la insulina y enfermedad cardiovascular Adiponectina: un nuevo nexo entre obesidad, resistencia a la insulina y enfermedad cardiovascular](/preview/png/9298732.png)
چکیده انگلیسی
Adiponectin is a novel and important member of the adipocytokine family which has regulatory functions in the glucose and lipid metabolism. Adiponectin stimulates fatty acids oxidation, reduces plasma triglycerides, and improves glucose metabolism by increasing the insulin sensitivity. In addition, adiponectin inhibits the inflammatory process that accompanies atherogenesis, as it reduces the expression of endothelial adhesion molecules, macrophage-to-foam cell transformation, tumor necrosis factor-α (TNF-α) expression in macrophages and adipocytes, and smooth muscle cell proliferation. Several insulin-resistant states, such as obesity and type 2 diabetes, or cardiovascular diseases, have been found to be associated with low levels of plasma adiponectin. Thus, therapeutic approaches aimed at increasing the adiponectin concentrations or the adiponectin tissue sensitivity and action could represent a novel treatment strategy for insulin resistance in type 2 diabetes and might have therapeutic implications as an anti-obesity drug or as an anti-atherogenic plasma protein.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medicina ClÃnica - Volume 124, Issue 10, March 2005, Pages 388-395
Journal: Medicina ClÃnica - Volume 124, Issue 10, March 2005, Pages 388-395
نویسندگان
Xavier Palomer, Antonio Pérez, Francisco Blanco-Vaca,