Studies on unfolded β2-microglobulin at C-terminal in dialysis-related amyloidosis

This study demonstrates that the monoclonal antibody specific to the C-terminal 92-99 of β2m can detect the conformational intermediate in amyloidogenesis of β2m ex vivo, and demonstrates that an unfolded β2m at C-terminal could be found not only in Congophilic area but even in non-Congophilic area as well.