Keywords: اشتباه; Misfolding; Aggregation; Pyrazole; HSP90; Sensors;
مقالات ISI اشتباه (ترجمه نشده)
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Keywords: اشتباه; Alpha-synuclein; Parkinson; Prion; Spreading; Misfolding;
Keywords: اشتباه; Prion; Strain; Misfolding;
Keywords: اشتباه; Alpha-1 antitrypsin deficiency; Liver disease; Conformational disease; Misfolding; Protein evolution; Déficit en alpha-1 antitrypsine; Maladie hépatique; Maladies conformationnelles; Défaut de repliement; Ãvolution protéique;
Keywords: اشتباه; AD; Alzheimer's disease; ANS; 1-anilinonaphthalene-8-sulfonic acid; AS; α-synuclein; CMC; critical micellar concentration; CTE; chronic traumatic encephalopathy; EPR; electron paramagnetic; ETeff; energy transfer efficiency; FRET; Förster resonance en
Structural analysis of misfolding equilibrative nucleoside transporter 3in H-syndrome
Keywords: اشتباه; Equilibrative nucleoside transporter 3; Misfolding; I-TASSER; PyMOL;
Discovery of (2-aminophenyl)methanol as a new molecular chaperone that rescues the localization of P123S mutant pendrin stably expressed in HEK293 cells
Keywords: اشتباه; Hearing loss; Pendrin; P123S mutant; Misfolding; Molecular chaperone; Localization; Morphological analysis;
ReviewRare ER protein misfolding-mistrafficking disorders: Therapeutic developments
Keywords: اشتباه; Mutations; Misfolding; Trafficking; ERAD;
A single amino acid (Asp159) from the dog prion protein suppresses the toxicity of the mouse prion protein in Drosophila
Keywords: اشتباه; α1–3, helices 1–3; CaPrP, Canis PrP; MoPrP, mouse PrP; PrP, prion protein; WT, wild typePrion protein; Neurotoxicity; Dog; Mouse; Drosophila; Misfolding; Protective substitution; Sequence alignment
ERAP1 reduces accumulation of aberrant and disulfide-linked forms of HLA-B27 on the cell surface
Keywords: اشتباه; β2m, β2-microglobulin; HLA, human leukocyte antigen; MHC, major histocompatibility complex; ER, endoplasmic reticulum; ERAP1, ER aminopeptidase 1Epistasis; Major histocompatibility complex; Misfolding; Ankylosing spondylitis
Roles of methionine oxidation in E200K prion protein misfolding: Implications for the mechanism of pathogenesis in E200K linked familial Creutzfeldt–Jakob disease
Keywords: اشتباه; Prion protein; Methionine oxidation; Oxidative stress; Misfolding; E200K mutant; Familial Creutzfeldt–Jakob disease
The synergistic effect of antiglycating agents (MB-92) on inhibition of protein glycation, misfolding and diabetic complications in diabetic-atherosclerotic rat
Keywords: اشتباه; Combinatorial therapy; Glycated products; Misfolding; Aggregation; Diabetic complications; Atheromatose plaque; Crocetin; Amino acids; Streptozotocin;
Isoform separation of proteins by mixed-mode chromatography
Keywords: اشتباه; Mixed-mode; Arginine; Etanercept; Isoform; Misfolding
CHF5074 (CSP-1103) stabilizes human transthyretin in mice humanized at the transthyretin and retinol-binding protein loci
Keywords: اشتباه; CHF5074; [1-(3â²,4â²-dichloro-2-fluoro[1,1â²-biphenyl]-4-yl)-cyclopropane carboxylic acid]; RBP; retinol binding protein; T4; thyroxin; TTR; transthyretin; CHF5074 (CSP-1103); Familial amyloidotic polyneuropathy; Misfolding; Retinol binding protein; Tr
The N-terminal strand modulates immunoglobulin light chain fibrillogenesis
Keywords: اشتباه; Light chain; Amyloid; Misfolding; Aggregation; Folding thermodynamics;
Nanoprobing of misfolding and interactions of amyloid β 42 protein
Keywords: اشتباه; Amyloid beta; Misfolding; Single-molecule force spectroscopy; Contour length; Dimerization pathways;
Wild-type Cu/Zn superoxide dismutase stabilizes mutant variants by heterodimerization
Keywords: اشتباه; SOD1; Misfolding; Heterodimerization; Mutant homodimers; Protein aggregation; Dismutase activity; SEDI; USOD;
Amyloid beta(1-42) in aqueous environments: Effects of ionic strength and E22Q (Dutch) mutation
Keywords: اشتباه; Amyloid-beta; Alzheimer's disease; Amyloidogenesis; Misfolding; Molecular dynamics; Dutch mutation;
Molecular basis for the catalytic inactivity of a naturally occurring near-null variant of human ALOX15
Keywords: اشتباه; LOXs; lipoxygenases; ALOX; arachidonate lipoxygenase; 15-H(p)ETE; (5Z,8Z,11Z,13E)-15-hydroperoxyeicosa-5,8,11,13-tetraenoic acid; 13-H(p)ODE; (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoic acid; 12-H(p)ETE; (5Z,8Z,10E,14Z)-12-hydroperoxyeicosa-5,8,10,14
Understanding protein folding from globular to amyloid state: Aggregation: Darker side of protein
Keywords: اشتباه; ANS, 8-anilino-1-naphthalene-sulphonic acid; MG, molten globuleAggregation; Amyloid; Hydrophobic interactions; Intermediate states; Misfolding; Protein folding
Water's potential role: Insights from studies of the p53 core domain
Keywords: اشتباه; p53 core domain; Hydration; Molecular dynamics; Misfolding;
Protein-oxidized phospholipid interactions in cellular signaling for cell death: From biophysics to clinical correlations
Keywords: اشتباه; A2E; N-retinylidene-N-retinylethanolamine; 2DM; type 2 diabetes; apo; apolipoprotein; Aβ; Alzheimer β-peptide; AD; Alzheimer's disease; AMD; age-related macular degeneration; AMP; antimicrobial peptides; CMC; critical micelle concentration; cyt c; cytoc
A partially folded structure of amyloid-beta(1-40) in an aqueous environment
Keywords: اشتباه; Aβ; amyloid-β peptide; DSS; 4,4-dimethyl-4-silapentane-1-sulfonic acid; NOE; nuclear overhauser effect; MD; molecular dynamics; TOCSY; total correlation spectroscopy; NOESY; nuclear overhauser effect spectroscopy; NMR; nuclear magnetic resonance; Struct
Structural Change in β-Sheet A of Z α1-Antitrypsin Is Responsible for Accelerated Polymerization and Disease
Keywords: اشتباه; α1AT, α1-antitrypsin; ER, endoplasmic reticulum; RCL, reactive center loop; HNE, human neutrophil elastase; COSM, center of spectral mass; bis-ANS, 4,4′-dianilino-1,1′-binaphthyl-5,5′-disulfonic acid; SI, stoichiometry of inhibitionserpin; misfolding; agg
Intrinsically disordered proteins may escape unwanted interactions via functional misfolding
Keywords: اشتباه; Intrinsically disordered protein; Misfolding; Partially folded protein; Protein-protein interaction; Protein non-folding; Protein function;
Rescue of ER oxidoreductase function through polyphenolic phytochemical intervention: Implications for subcellular traffic and neurodegenerative disorders
Keywords: اشتباه; Protein disulfide isomerase; Nitrosative stress; Misfolding; Neurodegenerative disorders; S-nitrosylation; Polyphenolic phytochemicals
Purification of recombinant mandelate racemase: Improved catalytic activity
Keywords: اشتباه; Mandelate racemase; Immobilized metal ion affinity chromatography; Misfolding; StrepII-tag; Polyhistidine tag; TIM-barrel proteins
Mouse ApoM Displays an Unprecedented Seven-Stranded Lipocalin Fold: Folding Decoy or Alternative Native Fold?
Keywords: اشتباه; misfolding; refolding; alternative conformations; apolipoprotein; lipocalinm-apoM, mouse apolipoprotein M; h-apoM, human apolipoprotein M; SCR, structurally conserved region; MD, molecular dynamics; PDB, Protein Data Bank
Fibrinogen has chaperone-like activity
Keywords: اشتباه; Fibrinogen; Chaperone; Extracellular; Aggregation; Misfolding; Fibril formation
Physiological responses to protein aggregates: Fibrinolysis, coagulation and inflammation (new roles for old factors)
Keywords: اشتباه; Amyloid; Crossbeta; Haemostasis; Misfolding;
Smoking and Parkinson's disease: Does nicotine affect α-synuclein fibrillation?
Keywords: اشتباه; α-synuclein; Intrinsically disordered protein; Smoking; Parkinson's disease; Nicotine; Hydroquinone; Fibrillation; Misfolding;
Specific N-terminal mutations in the human androgen receptor induce cytotoxicity
Keywords: اشتباه; Kennedy's disease; SBMA; Drosophila; Neurodegeneration; CAG; Misfolding; Sodium butyrate; Melatonin
Structural differences between Pb2+- and Ca2+-binding sites in proteins: Implications with respect to toxicity
Keywords: اشتباه; Metalloprotein; Toxicity; Electrostatic; Opportunistic binding; Misfolding
Protein folding: Then and now
Keywords: اشتباه; Protein folding; Misfolding; Aggregation; Folding kinetics; Protein thermodynamics; Discrete molecular dynamics (DMD);
Different disturbances - one pathway of protein unfolding. Actin folding-unfolding and misfolding
Keywords: اشتباه; Protein folding; Misfolding; Intermediates; Energy landscape; Actin; Inactivated actin; GdnHCl; guanidine hydrochloride;
Effects of the single point genetic mutation D54G on muscle creatine kinase activity, structure and stability
Keywords: اشتباه; ANS; 1-anilinonaphtalene-8-sulfonate; CK; creatine kinase; BB-CK; brain CK; MM-CK; muscle CK; CD; circular dichroism; GdnHCl; guanidine hydrochloride; Emax; emission maximum wavelength of the intrinsic fluorescence; MG; molten globule intermediate; PCr; p
Modulation of polyglutamine inclusion formation by the Hsp70 chaperone machine
Keywords: اشتباه; Polyglutamine disease; Misfolding; Aggregation; Molecular chaperones; Protein quality control;
Confronting high-throughput protein refolding using high pressure and solution screens
Keywords: اشتباه; Inclusion bodies; Aggregation; Misfolding; Solubilization; Protein recovery; Protein refolding; Small molecules assisted refolding; Fractional factorial screen; High hydrostatic pressure; Automation; High-throughput; Structural genomics
Biotin–avidin interaction-based screening assay for Alzheimer’s β-peptide oligomer inhibitors
Keywords: اشتباه; Amyloid; High throughput; Misfolding; Single-site assay; Alzheimer’s
Nephrogenic Diabetes Insipidus
Keywords: اشتباه; AVPR2 mutations; AQP2 mutations; Prenatal testing; Misfolding; Pharmacologic chaperones;
Minimalist Protein Model as a Diagnostic Tool for Misfolding and Aggregation
Keywords: اشتباه; protein folding; misfolding; aggregation; minimalist model; gatekeeper
Retention of Misfolded Mutant Transthyretin by the Chaperone BiP/GRP78 Mitigates Amyloidogenesis
Keywords: اشتباه; BiP; misfolding; intermediate; amyloid; oligomerCNS, central nervous system; CSF, cerebrospinal fluid; TTR, transthyretin; FAP, familial amyloidotic polyneuropathy; ER, endoplasmic reticulum; Hsp, heat shock protein; D18G, mutant with an aspartate to glyc
Misfolding of glycoproteins is a prerequisite for peptide: N-glycanase mediated deglycosylation
Keywords: اشتباه; Peptide:N-glycanase; Glycoprotein; Misfolding; Deglycosylation; Circular dichroism;
Pkc1p modifies CPY* degradation in the ERAD pathway
Keywords: اشتباه; Misfolding; Glycoprotein; Cdc48p;
Low temperature completely rescues the function of two misfolded KATP channel disease-mutants
Keywords: اشتباه; PCR, polymerase chain reaction; ER, endoplasmic recticulumPotassium channels; Hyperinsulinism; Temperature sensitive; Mutations; Misfolding
Studies on unfolded β2-microglobulin at C-terminal in dialysis-related amyloidosis
Keywords: اشتباه; β2-microglobulin; dialysis-related amyloidosis; misfolding;
Differential degradation of variant medium-chain acyl-CoA dehydrogenase by the protein quality control proteases Lon and ClpXP
Keywords: اشتباه; Mitochondrial; Variant protein; Misfolding; Degradation; Protein quality control; Proteases; Chaperones;