کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2189032 | 1096194 | 2006 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Minimalist Protein Model as a Diagnostic Tool for Misfolding and Aggregation
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Minimalist Protein Model as a Diagnostic Tool for Misfolding and Aggregation Minimalist Protein Model as a Diagnostic Tool for Misfolding and Aggregation](/preview/png/2189032.png)
چکیده انگلیسی
We propose a realistic coarse-grained protein model and a technique to “anchor” the model to available experimental data. We apply this procedure to characterize the effect of multiple mutations on the folding mechanism of protein S6. We show that the mutation of a few “gatekeeper” residues triggers significant changes on the folding landscape of S6. These results suggest that gatekeeper residues control the flexibility of critical regions of S6, that in turn regulates the delicate balance between folding and aggregation. Although obtained with a minimalist protein model, these results are fully consistent with experimental evidence and offer a clue to understand the interplay between folding and aggregation in protein S6.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Biology - Volume 363, Issue 1, 13 October 2006, Pages 297–308
Journal: Journal of Molecular Biology - Volume 363, Issue 1, 13 October 2006, Pages 297–308
نویسندگان
Silvina Matysiak, Cecilia Clementi,