EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: Evidence for a PPAR-γ-dependent mechanism

Our data demonstrate that both EPA and DHA down-regulate LPS-induced activation of NF-κB via a PPAR-γ-dependent pathway in HK-2 cells. These results suggest that PPAR-γ activation by EPA and DHA may be one of the underlying mechanisms for the beneficial effects of fish oil.