Cardiovascular Safety of Tamsulosin Modified Release in the Fasted and Fed State in Elderly Healthy Subjects

Vital signs and orthostatic stress testing are more influenced by tamsulosin 0.4 mg MR capsules in the fasted than in the fed state. As tamsulosin MR is intended to be taken after breakfast or the first meal of the day, lack of compliance with this instruction may increase the incidence of cardiovascular adverse events in elderly males.