کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9331749 | 1255873 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Presence of the P2X7 purinergic receptor on immune cells that invade the rat endometrium during oestrus
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Eosinophils, macrophages and other leucocytes invade the uterine endometrium during oestrus and play a role in the tissue remodeling and immune responses that occur prior to implantation of the fertilized ovum. Adenosine 5â²-triphosphate (ATP) and its metabolites influence uterine function via ATP receptors. In this study, we investigated the presence and localisation of the P2X7 nucleotide receptor in the cells that infiltrate the uterine endometrium of adult female rats during oestrus at the electron microscope level, using gold-silver pre-embedding immunocytochemical techniques. P2X7 receptor expression was found in the cytoplasm and the cell membrane of eosinophils, macrophages and fibroblasts in the endometrium during oestrus. These results suggest that ATP-mediated responses may be important in uterine preparation and remodeling before implantation and that this may involve several types of cells. In particular, the presence of P2X7 receptors on endometrial stromal cells may indicate their involvement in apoptosis and immune and inflammatory responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Reproductive Immunology - Volume 66, Issue 2, August 2005, Pages 127-140
Journal: Journal of Reproductive Immunology - Volume 66, Issue 2, August 2005, Pages 127-140
نویسندگان
Rachel Koshi, Robson Coutinho-Silva, Cynthia Machado Cascabulho, Andrea Henrique-Pons, Gillian E. Knight, Andrzej Loesch, Geoffrey Burnstock,