Changing genetic world of IVF, stem cells and PGD. C. Embryogenesis and the differentiation of the haemopoietic system

In this final review, attention is focused on the formation of several haemopoietic systems and their genetic markers. Very early haemopoietic precursors have been identified in mesoderm and yolk sac, as interactions arise between haemopoietic stem cells (HSC) and mesenchymal stem cells (MSC). The foundation cell for the haemopoietic system has not been identified, although several candidate cells carrying specific markers have been recognized and are highly pluripotent. Haemangioblasts were proposed as the founder haemopoietic stem cell. They may be the source of pluripotent haemopoietic cells formed in blastocyst injection chimaeras, a characteristic typical of ES cells. Their role as the founder cell of haemopoietic and mesenchymal tissues is discussed.