Comparative effects of TGF-β1 and TGF-β2 on extracellular matrix production, proliferation, migration, and collagen contraction of human Tenon's capsule fibroblasts in pseudoexfoliation and primary open-angle glaucoma

Conclusions. These findings suggest a significant contribution of TGF-β1 in addition to TGF-β2 to the conjunctival scarring process following glaucoma filtration surgery. Due to its pronounced fibrogenic potential, TGF-β1 may become another focus for targeting drug therapy, particularly in patients with PEX glaucoma.