کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9345600 | 1262359 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nouveaux concepts étiologiques dans l'uvéite
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کلمات کلیدی
Epidemiology - اپیدمیولوژی(همهگیرشناسی)Lyme disease - بیماری لایمMaladie de Lyme - بیماری لیمWhipple's disease - بیماری وایپلDiagnosis - تشخیصDiagnostic - تشخیصamplification génique - تقویت ژنRetinitis - رتینیتMaladie de Whipple - مالدی د وایپلÉpidémiologie - همهگیرشناسیPCR - واکنش زنجیرهٔ پلیمرازuveitis - یوئیتUvéites - یووئیت
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
چشم پزشکی
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چکیده انگلیسی
Uveitis remains an important cause of visual impairment, particularly in young patients. Idiopathic forms of intraocular inflammation should no longer be regarded as a presumed clinical entity, and the ophthalmologist must reconsider the specific etiology of primary uveitis when the clinical examination does not yield a definitive diagnosis or when the course of the disease on corticosteroids remains atypical. Laboratory tests based on serum analysis have limited value and should not be considered as diagnostic proof in different clinical presentations. The diagnostic management of infectious uveitis has been greatly improved by the use of molecular techniques applied to ocular fluids and tissues. Polymerase chain reaction (PCR) technology is a powerful tool that should be proposed in atypical cases of uveitis or retinitis of unclear but potentially infectious origin. This strategy is a major step before using unconventional and new immunomodulatory agents such as anti-TNF-alpha molecules. Under strict experimental conditions including adequate testing to rule out a possible contamination, PCR and its variants have changed our practical approach to intraocular inflammatory disorders and have provided new details for the understanding of infectious uveitis. The concept of pathogen-induced intraocular inflammation can be revisited in the light of molecular data obtained after anterior chamber paracentesis or diagnostic vitrectomy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal Français d'Ophtalmologie - Volume 28, Issue 5, May 2005, Pages 547-555
Journal: Journal Français d'Ophtalmologie - Volume 28, Issue 5, May 2005, Pages 547-555
نویسندگان
B. Bodaghi,