کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9353895 | 1266793 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pulsed electromagnetic field treatments enhance the healing of fibular osteotomies
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
ارتوپدی، پزشکی ورزشی و توانبخشی
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چکیده انگلیسی
This study tested the hypothesis that pulsed electromagnetic field (PEMF) treatments augment and accelerate the healing of bone trauma. It utilized micro-computed tomography imaging of live rats that had received bilateral 0.2Â mm fibular osteotomies (â¼0.5% acute bone loss) as a means to assess the in vivo rate dynamics of hard callus formation and overall callus volume. Starting 5Â days post-surgery, osteotomized right hind limbs were exposed 3Â h daily to Physio-Stim® PEMF, 7Â days a week for up to 5Â weeks of treatment. The contralateral hind limbs served as sham-treated, within-animal internal controls. Although both PEMF- and sham-treatment groups exhibited similar onset of hard callus at â¼9Â days after surgery, a 2-fold faster rate of hard callus formation was observed thereafter in PEMF-treated limbs, yielding a 2-fold increase in callus volume by 13-20Â days after surgery. The quantity of the new woven bone tissue within the osteotomy sites was significantly better in PEMF-treated versus sham-treated fibulae as assessed via hard tissue histology. The apparent modulus of each callus was assessed via a cantilever bend test and indicated a 2-fold increase in callus stiffness in the PEMF-treated over sham-treated fibulae. PEMF-treated fibulae exhibited an apparent modulus at the end of 5-weeks that was â¼80% that of unoperated fibulae. Overall, these data indicate that Physio-Stim® PEMF treatment improved osteotomy repair. These beneficial effects on bone healing were not observed when a different PEMF waveform, Osteo-Stim®, was used. This latter observation demonstrates the specificity in the relationship between waveform characteristics and biological outcomes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Orthopaedic Research - Volume 23, Issue 5, September 2005, Pages 1035-1046
Journal: Journal of Orthopaedic Research - Volume 23, Issue 5, September 2005, Pages 1035-1046
نویسندگان
Ronald J. Midura, Michael O. Ibiwoye, Kimerly A. Powell, Yoshitada Sakai, Todd Doehring, Mark D. Grabiner, Thomas E. Patterson, Maciej Zborowski, Alan Wolfman,