کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9353917 1266793 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evidence of tendon microtears due to cyclical loading in an in vivo tendinopathy model
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ارتوپدی، پزشکی ورزشی و توانبخشی
پیش نمایش صفحه اول مقاله
Evidence of tendon microtears due to cyclical loading in an in vivo tendinopathy model
چکیده انگلیسی
Tendon injuries at the epicondyle can occur in athletes and workers whose job functions involve repetitive, high force hand activities, but the early pathophysiologic changes of tendon are not well known. The purpose of this study was to evaluate early tendon structural changes, specifically the formation of microtears, caused by cyclical loading. The Flexor Digitorum Profundus (FDP) muscle of nine New Zealand White rabbits was stimulated to contract repetitively for 80 h of cumulative loading over 14 weeks. The contralateral limb served as a control. The tendon at the medial epicondyle insertion site was harvested, sectioned, and stained. Microtears were quantified, using image analysis software, in four regions of the tendon, two regions along the enthesis and two distal to the enthesis. The tear density (loaded: 1329 ± 546 tears/mm2; unloaded: 932 ± 474 tears/mm2) and mean tear size (loaded: 18.3 ± 6.1 μm2; unloaded: 14.0 ± 4.8 μm2) were significantly greater in the loaded limb (p < 0.0001) across all regions compared to the unloaded contralateral limb. These early microstructural changes in a repetitively loaded tendon may initiate a degenerative process that leads to tendinosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Orthopaedic Research - Volume 23, Issue 5, September 2005, Pages 1199-1205
نویسندگان
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