کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9353938 | 1266794 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Biomechanical and allergological characteristics of a biodegradable poly(d,l-lactic acid) coating for orthopaedic implants
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
ارتوپدی، پزشکی ورزشی و توانبخشی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Biomechanical and allergological characteristics of a biodegradable poly(d,l-lactic acid) coating for orthopaedic implants Biomechanical and allergological characteristics of a biodegradable poly(d,l-lactic acid) coating for orthopaedic implants](/preview/png/9353938.png)
چکیده انگلیسی
A poly(d,l-lactic acid) surface coating (PDLLA) has been developed to optimize interactions at the implant-tissue interface. Mechanical and allergological characteristics were evaluated in the present study to elucidate possible indications and limitations prior to clinical application. Implants of stainless steel and Ti-6Al-4V and Co-Cr-Mo alloys were coated with PDLLA, and mechanical stability was studied during intramedullary implantation into rat and human cadaver bones and during dilation of coronary artery stents. Elongation resistance was examined on AlMgSi alloy specimens. Furthermore, proliferation of peripheral blood mononuclear cells of nickel-allergic donors and controls and interleukin-4 and interferon-γ levels were measured in the presence of coated/uncoated implants and after stimulation with phytohemagglutinin or NiSO4. PDLLA remained stable on the implants with a minimum of 96% of the original coating mass and tolerated lengthening of at least 8%. Further lengthening was followed by microcracking and cohesive failure within the coating. PDLLA exerted no suppressive effect upon spontaneous and pan-T-cell mitogen inducible T-cell proliferation. Furthermore, specific proliferation to nickel in cells of nickel-allergic blood donors and production of interleukin-4 and IFN-γ were not influenced by the coating. PDLLA coating proved high mechanical stability on different orthopaedic implants and did not influence in vitro T-cell reactivity towards specific biomaterials.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Orthopaedic Research - Volume 23, Issue 4, July 2005, Pages 802-809
Journal: Journal of Orthopaedic Research - Volume 23, Issue 4, July 2005, Pages 802-809
نویسندگان
Hans Gollwitzer, Peter Thomas, Peter Diehl, Erwin Steinhauser, Burkard Summer, Sonja Barnstorf, Ludger Gerdesmeyer, Wolfram Mittelmeier, Axel Stemberger,