کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9354941 1266893 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Gene expression of bone-resorbing cytokines in rat osteolysis model
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ارتوپدی، پزشکی ورزشی و توانبخشی
پیش نمایش صفحه اول مقاله
Gene expression of bone-resorbing cytokines in rat osteolysis model
چکیده انگلیسی
Osteolysis after single-injection polyethylene (PE) administration has been analyzed, but this experimental model did not reflect the clinical postoperative condition. Therefore, we investigated the bone-resorbing cytokines interleukin and tumor necrosis factor (IL-1a, IL-6, TNFa) produced by continuous PE administration using histomor- phologic findings and the reverse transcription polymerase chain reaction. TNFa mRNA was continuously detected in the PE continuous-infusion group, whereas it was not expressed in the PE single-injection group. IL-1a and IL-6 mRNA were detected in both groups. As for histomor- phological findings, in the PE continuous-infusion group proliferating fibrous tissue penetrated subchondral bone and the interface membrane around the K-wire inserted into the femur. Numerous osteoclasts were observed in the vicinity of resorbed bone. In the PE single-injection group, proliferation of fibrous tissue with bone resorption was not observed. TNFa may play a major role in fibrous tissue formation and osteoclastic bone resorption caused by PE debris. This osteolysis model is useful for investigating osteolysis associated with bone-resorbing cytokines under conditions similar to those seen with a human prosthesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Orthopaedic Science - Volume 10, Issue 1, February 2005, Pages 62-69
نویسندگان
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