کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9355078 | 1266899 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Distribution of sodium channels during nerve elongation in rat peripheral nerve
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
ارتوپدی، پزشکی ورزشی و توانبخشی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Distribution of sodium channels during nerve elongation in rat peripheral nerve Distribution of sodium channels during nerve elongation in rat peripheral nerve](/preview/png/9355078.png)
چکیده انگلیسی
A number of studies have investigated electrophy-siological and morphological changes of peripheral nerves during gradual elongation. There has been, however, no report on the distribution of sodium channels at Ranvier's nodes during peripheral nerve elongation. We investigated peripheral nerve injury after the gradual elongation of rat sciatic nerves. Indirect nerve elongation was induced by leg lengthening at a rate of 3Â mm/day by 15 or 30Â mm. At 7Â days after the leg lengthening, the electrophysiological properties of sciatic nerves, the ultrastructures of the Ranvier's nodes and axons, and the distribution of voltage-dependent sodium channels were examined. In the control nerves, most sodium channels were localized at Ranvier's nodes in myelinated axons, providing the physiological basis of saltatory conduction. In the elongated nerves, both the amplitude and conduction velocity of compound nerve action potential decreased following leg lengthening. The elongated nerves also showed paranodal demyelination in Ranvier's nodes longer than those in the control group. In addition, the distribution of sodium channels became diffuse or disappeared at Ranvier's nodes of elongated nerves. The diffuse distribution and/or disappearance of sodium channels may underlie the electrophysiological changes in compound nerve action potential induced by nerve elongation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Orthopaedic Science - Volume 10, Issue 2, March 2005, Pages 214-220
Journal: Journal of Orthopaedic Science - Volume 10, Issue 2, March 2005, Pages 214-220
نویسندگان
Harumitsu Ichimura, Takashi Shiga, Ichiro Abe, Yuki Hara, Naoto Terui, Akihito Tsujino, Naoyuki Ochiai,