کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9365655 | 1271519 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
c-myc amplification is associated with HER2 amplification and closely linked with cell proliferation in tissue microarray of nonselected breast cancers
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
آسیبشناسی و فناوری پزشکی
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چکیده انگلیسی
c-myc and HER2 amplification were analyzed on 214 consecutive breast cancers by fluorescence in situ hybridization using tissue microarray technology. The frequencies of amplification were 15.4% (33/214) and 23.3% (49/210), respectively. c-myc amplification was significantly associated with HER2 amplification (P < .001) and closely linked with cell proliferative activity, measured by Ki67 labeling index (P = .010). In univariate survival analysis, lymph node status, tumor size, and histological grade were significant prognostic factors, but in multivariate analysis, lymph node status was the only significant factor. Patient survival did not differ according to c-myc amplification status, and c-myc amplification showed no significant correlation with clinicopathologic features of the tumors. A strong correlation between c-myc and HER2 amplification and proliferative activity indicates a biological link between these genes in breast cancer cell.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Pathology - Volume 36, Issue 6, June 2005, Pages 634-639
Journal: Human Pathology - Volume 36, Issue 6, June 2005, Pages 634-639
نویسندگان
Kyeongmee MD, PhD, Keumhee MD, Jungyeon MD, PhD, Sungjig MD, PhD, Sehwan MD, PhD, FACS,