GADD45-α expression in cirrhosis and hepatocellular carcinoma: relationship with DNA repair and proliferation

In conclusion, GADD45-α mRNA was down-regulated with respect to matched cirrhosis in most HCCs; however, no correlation was found between mRNA and protein levels. GADD45-α protein levels were higher in HCCs with DNA-bound CDKN1A and PCNA, suggesting a possible role in DNA repair.