کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
936616 1475169 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Memory expression is independent of memory labilization/reconsolidation
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Memory expression is independent of memory labilization/reconsolidation
چکیده انگلیسی


• AMPA antagonism pre-reminder disrupts memory reconsolidation, but not memory expression.
• NMDA antagonism pre-reminder disrupts memory expression.
• And disrupts reconsolidation only if new information is available.
• Therefore, memory expression is unnecessary for reconsolidation.

There is growing evidence that certain reactivation conditions restrict the onset of both the destabilization phase and the restabilization process or reconsolidation. However, it is not yet clear how changes in memory expression during the retrieval experience can influence the emergence of the labilization/reconsolidation process. To address this issue, we used the context-signal memory model of Chasmagnathus. In this paradigm a short reminder that does not include reinforcement allows us to evaluate memory labilization and reconsolidation, whereas a short but reinforced reminder restricts the onset of such a process. The current study investigated the effects of the glutamate antagonists, APV (0.6 or 1.5 μg/g) and CNQX (1 μg/g), prior to the reminder session on both behavioral expression and the reconsolidation process. Under conditions where the reminder does not initiate the labilization/reconsolidation process, APV prevented memory expression without affecting long-term memory retention. In contrast, APV induced amnesic effects in the long-term when administered before a reminder session that triggers reconsolidation. Under the present parametric conditions, the administration of CNQX prior to the reminder that allows memory to enter reconsolidation impairs this process without disrupting memory expression. Overall, the present findings suggest that memory reactivation – but not memory expression- is necessary for labilization and reconsolidation. Retrieval and memory expression therefore appear not to be interchangeable concepts.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Learning and Memory - Volume 106, November 2013, Pages 283–291
نویسندگان
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