کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
936624 | 1475168 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nogo-A downregulation impairs place avoidance in the Carousel maze but not spatial memory in the Morris water maze
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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![عکس صفحه اول مقاله: Nogo-A downregulation impairs place avoidance in the Carousel maze but not spatial memory in the Morris water maze Nogo-A downregulation impairs place avoidance in the Carousel maze but not spatial memory in the Morris water maze](/preview/png/936624.png)
چکیده انگلیسی
Nogo-A protein is an important inhibitor of axonal growth, which also regulates neuronal plasticity in the CNS. Mutations in the gene encoding Nogo-A or abnormalities in Nogo-A expression are linked to neuropsychiatric disorders such as schizophrenia. The present study assesses the impact of constitutively reduced expression of Nogo-A on place navigation in a novel transgenic rat model. Two spatial paradigms were used: (1) A battery of tests in the Carousel maze requiring continuous processing of spatial information with increasing demands for the segregation of reference frames and behavioral flexibility and (2) a delayed-matching-to-place version of the Morris water maze (MWM), which requires place navigation and is sensitive to deficits in one-trial-encoded place representation. The Carousel maze testing revealed a subtle but significant impairment in management of reference frames. Matching-to-place learning in the Morris water maze was unaffected, suggesting an intact representation of an unmarked goal. Our results show that Nogo-A deficiency leads to cognitive deficit in processing of the reference frames. Such a deficit may be the result of neuro-developmental alterations resulting from Nogo-A deficiency.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Learning and Memory - Volume 107, January 2014, Pages 42-49
Journal: Neurobiology of Learning and Memory - Volume 107, January 2014, Pages 42-49
نویسندگان
Tomas Petrasek, Iva Prokopova, Stepan Bahnik, Kai Schonig, Stefan Berger, Karel Vales, Bjorn Tews, Martin E. Schwab, Dusan Bartsch, Ales Stuchlik,