کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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936815 | 1475195 | 2010 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Acquisition of glucose-conditioned flavor preference requires the activation of dopamine D1-like receptors within the medial prefrontal cortex in rats Acquisition of glucose-conditioned flavor preference requires the activation of dopamine D1-like receptors within the medial prefrontal cortex in rats](/preview/png/936815.png)
In this study, we investigated the role of dopamine transmission within the medial prefrontal cortex (mPFC) in flavor preference learning induced by post-oral glucose. In Experiment 1, rats were trained with a flavor (CS+) paired with intragastric (IG) infusions of 8% glucose and a different flavor (CS−) paired with IG water infusions. The CS+ preference was evaluated in two-bottle tests following bilateral injection of the dopamine D1-like receptor antagonist, SCH23390, into the mPFC at total doses of 0, 12 and 24 nmol. SCH23390 produced dose-dependent reductions in CS+ intake but did not block the CS+ preference. In Experiment 2, new rats were injected daily in the mPFC with either saline or SCH23390 (12 nmol), prior to training sessions with CS+/IG glucose and CS−/IG water. In the two-bottle choice tests, SCH rats, unlike the Control rats, failed to prefer the CS+ (50% vs. 74%). Collectively, the results show that D1-like receptor activation in the medial prefrontal cortex plays a crucial role in the acquisition of flavor preference learning induced by the post-oral reinforcing properties of glucose.
Journal: Neurobiology of Learning and Memory - Volume 94, Issue 2, September 2010, Pages 214–219