کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
936894 1475201 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of rodent prefrontal lesions on object-based, visual scene memory
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Effects of rodent prefrontal lesions on object-based, visual scene memory
چکیده انگلیسی

It has been suggested that certain prefrontal areas contribute to a neural circuit that mediates visual object memory. Using a successive go/no-go visual scene discrimination task, object-based long-term memory was assessed in two rodent prefrontal regions. Rewarded trials consisted of a standard scene of four toy objects placed over baited food wells. The objects and their locations composing the standard scene remained constant for the duration of the study. Trials in which one of the standard scene objects was replaced with a novel object were not rewarded. Following the establishment of a significant difference between latency to approach the rewarded standard scene compared to latency to approach non-rewarded scenes, quinolinic acid or control vehicle was infused into either the prelimbic and infralimbic cortices or the anterior cingulate cortex. Following a 1 week recovery period, subjects were retested. Animals with prelimbic/infralimbic cortex lesions displayed a profound and sustained deficit, whereas, animals with anterior cingulate cortex lesions showed a slight initial impairment but eventually recovered. Both lesion groups acquired a simple single object discrimination task as quickly as controls indicating that the deficits on the original scene discrimination task were not due to motivational, response inhibition, or perceptual problems.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Learning and Memory - Volume 92, Issue 4, November 2009, Pages 552–558
نویسندگان
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