کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
936902 1475206 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chronic oral methylphenidate induces post-treatment impairment in recognition and spatial memory in adult rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Chronic oral methylphenidate induces post-treatment impairment in recognition and spatial memory in adult rats
چکیده انگلیسی

Recent pre-clinical research has indicated that chronic treatment with methylphenidate (Ritalin®) in young animals can result in lasting and potentially detrimental alterations in brain function that can persist into adulthood. Chronic methylphenidate-induced neuronal alterations may result in behavior and cognitive deficits that include increases in behavioral responses and impairment in recognition memory. This study compared the cognitive consequences following chronic treatment with two doses (5 and 10 mg/kg) of methylphenidate on recognition and spatial memory in adult male Long-Evans rats using an established oral dosing procedure. The animals were then tested in the Object Recognition test at 14 days post treatment and the Object Placement test at 21 days post treatment. The results indicate that repeated exposure to oral methylphenidate impaired the performance of rats in these tests. The current findings add to recent research demonstrating negative consequences in rats pre-treated with methylphenidate, and extend previous findings to include deficits in spatial recognition memory.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Learning and Memory - Volume 91, Issue 3, March 2009, Pages 218–225
نویسندگان
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